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News Archive - Heather Buschman, PhD

Gut Microbes Influence How Rat Brains React to Opioids

April 27, 2020

Antibiotic treatment — which depletes gut microbes — drastically changes the parts of a rat’s brain that are activated during opioid addiction and withdrawal.

UC San Diego to Advance Stem Cell Therapies in New Space Station Lab

April 8, 2020

UC San Diego and Space Tango received a NASA award to develop the first dedicated stem cell research laboratory within the International Space Station.

Artificial Intelligence Enables Rapid COVID-19 Lung Imaging Analysis at UC San Diego Health

April 7, 2020

With support from Amazon Web Services, UC San Diego Health physicians are using AI in a clinical research study aimed at speeding the detection of pneumonia, a condition associated with severe COVID-19.

How Sperm Unpack Dad’s Genome so it Can Merge with Mom’s

March 13, 2020

UC San Diego researchers discover the enzyme SPRK1’s role in reorganizing the paternal genome during the first moments of fertilization — a finding that might help explain infertility cases of unknown cause.

Microbial DNA in Patient Blood May be Tell-Tale Sign of Cancer

March 11, 2020

From a simple blood draw, microbial DNA may reveal who has cancer and which type, even at early stages.

How Resident Microbes Restructure Body Chemistry

February 26, 2020

A comparison of normal and germ-free mice revealed that as much as 70 percent of a mouse’s gut chemistry is determined by its gut microbiome. Even in distant organs, such as the uterus or the brain, approximately 20 percent of molecules were different in the mice with gut microbes.

More than Just a Carnival Trick: Researchers Can Guess Your Age Based on Your Microbes

February 11, 2020

UC San Diego and IBM researchers reveal a new understanding of how our microbiomes change as we age, setting the stage for future research on the role microbes play in accelerating or decelerating the aging process and influencing age-related diseases.

Human Gut-in-a-Dish Model Helps Define ‘Leaky Gut,’ and Outline a Pathway to Treatment

February 10, 2020

UC San Diego researchers use 3D human gut organoids to reveal the molecular system that keeps intestinal linings sealed, demonstrate how the system breaks down and how it can be strengthened with the diabetes drug metformin.

Liver Fibrosis ‘Off Switch’ Discovered in Mice

January 23, 2020

UC San Diego School of Medicine researchers identified several genetic switches, or transcription factors, that determine whether or not liver cells produce collagen — providing a new therapeutic target for liver fibrosis.

Zika Virus’ Key into Brain Cells ID’d, Leveraged to Block Infection and Kill Cancer Cells

January 16, 2020

Two different UC San Diego research teams identified the same molecule — αvβ5 integrin — as Zika virus’ key to brain cell entry. They found ways to take advantage of the integrin to both block Zika virus from infecting cells and turn it into something good: a way to shrink brain cancer stem cells.
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